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Gene Information
Gene ID:19342
Symbol:Rab4b
Full Name:RAB4B, member RAS oncogene family
Alias:1500031G17Rik
Organism:Mus musculus (Mouse)
Chromosome:7
Genetic Location:7 A3|7 7.4 cM
Physical Location:27953451-27963901 on NC_000073.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 53916    Symbol (Name): RAB4B (RAB4B, member RAS oncogene family)
Ortholog Status:The human GeneID 53916 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rab4b
Fold Change:0.73
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_029391.2NP_083667.1NC_000073.5 range: 27953451..27963901, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005525GTP bindingMolecular FunctionIEA
GO:0006810transportBiological ProcessIEA
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
GO:0015031protein transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:19342
MGI:
Ensembl:ENSMUSG00000053291
dbSNP:Rab4b
AceView:Rab4b