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Gene Information
Gene ID:1950
Symbol:EGF
Full Name:epidermal growth factor (beta-urogastrone)
Alias:HOMG4|URG
Organism:Homo sapiens (Human)
Chromosome:4
Genetic Location:4q25
Physical Location:111053498-111152867 on NC_000004.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:EGF
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D4S4232.610.000392691777
D4S4273.530.00003121646580
Region:92691777-121646580
Phenotype:ADSX (number of DSM-IV AD symptoms)
Name:16534506
Method:Linkage
Publication:Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed
Summary:We conducted a genome scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). A 4 cM genome scan was conducted using 474 families of which most (96%) were comprised by affected sib pairs. Nonparametric and quantitative linkage analyses were conducted using DSM-IV alcohol dependence (AD) and number of DSM-IV AD symptoms (ADSX). Quantitative results indicate strong linkage for number of AD criteria to a broad region of chromosome 4, ranging from 4q22 to 4q32 (peak multipoint LOD=4.59, P=2.1 x 10(-6), at D4S1611). We got the gene list in the region between two markers D4S423 and D4S427 as markers between (included) these two markers have LOD scores >2 with P value <0.0003.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001963.3NP_001954.2NC_000004.10 range: 111053498..111152867
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0031093platelet alpha granule lumenCellular ComponentEXP (6603475)
GO:0005886plasma membraneCellular ComponentTAS (3491360)
GO:0005634nucleusCellular ComponentNR
GO:0005576extracellular regionCellular ComponentIC (9712850)
GO:0005576extracellular regionCellular ComponentEXP (6603475|8493579|8639530|8845374|9356464|9544989|10567358|10648629|10734310|10913131|11823423|1189409)
GO:0005515protein bindingMolecular FunctionIPI (12620237)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005155epidermal growth factor receptor activating ligand activityMolecular FunctionTAS (9712850)
GO:0008083growth factor activityMolecular FunctionIDA (15611079)
GO:0045741positive regulation of epidermal growth factor receptor activityBiological ProcessIDA (15611079)
GO:0042327positive regulation of phosphorylationBiological ProcessIDA (15611079)
GO:0045840positive regulation of mitosisBiological ProcessIDA (15611079)
GO:0000187activation of MAPK activityBiological ProcessTAS (9482941)
GO:0008284positive regulation of cell proliferationBiological ProcessIDA (15611079)
GO:0007165signal transductionBiological ProcessEXP (1501243)
GO:0006260DNA replicationBiological ProcessTAS (9482941)
GO:0001525angiogenesisBiological ProcessIDA (15611079)
GO:0051048negative regulation of secretionBiological ProcessIDA (10559227)
Other Database Cross Links
NCBI Entrez Gene:1950
HGNC:3229
Ensembl:ENSG00000138798
MIM:131530
HPRD:00578
HuGE Navigator:1950
dbSNP:EGF
GeneCard:EGF
AceView:EGF