ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rps3a

Full Name:

ribosomal protein S3a

Alias:

MGC102469|MGC117914

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

3 F1

Physical Location:

85941867-85946514 on NC_000069.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6189 Symbol (Name): RPS3A (ribosomal protein S3A)

Ortholog Status:

The human GeneID 6189 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rps3a
Fold Change:		1.23
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016959.3	NP_058655.2	NC_000069.5 range: 85941867..85946514, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (10713066)
GO:0005829	cytosol	Cellular Component	IDA (10713066)
GO:0005840	ribosome	Cellular Component	IEA
GO:0030529	ribonucleoprotein complex	Cellular Component	IEA
GO:0003735	structural constituent of ribosome	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10713066)
GO:0006412	translation	Biological Process	IEA