ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Scn1b

Full Name:

sodium channel, voltage-gated, type I, beta

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 B1|7 10.0 cM

Physical Location:

31901542-31911963 on NC_000073.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6324 Symbol (Name): SCN1B (sodium channel, voltage-gated, type I, beta)

Ortholog Status:

The human GeneID 6324 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Scn1b
Fold Change:		0.61
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011322.2	NP_035452.1	NC_000073.5 range: 31901542..31911963, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0005272	sodium channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA