ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Scn8a

Full Name:

sodium channel, voltage-gated, type VIII, alpha

Alias:

AI853486|C630029C19Rik|NaCh6|Nav1.6|dmu|med|nmf2|nmf335|nmf58|seal

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 F1|15 60.0 cM

Physical Location:

100701113-100876359 on NC_000081.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6334 Symbol (Name): SCN8A (sodium channel, voltage gated, type VIII, alpha subunit)

Ortholog Status:

The human GeneID 6334 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001077499.1	NP_001070967.1	NC_000081.5 range: 100701113..100876359

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043025	cell soma	Cellular Component	IDA (17928448)
GO:0001518	voltage-gated sodium channel complex	Cellular Component	IC (9828131)
GO:0030425	dendrite	Cellular Component	IDA (17928448)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	IDA (17537961)
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0005248	voltage-gated sodium channel activity	Molecular Function	NAS (9828131)
GO:0005272	sodium channel activity	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0007628	adult walking behavior	Biological Process	IMP (7670495)
GO:0007626	locomotory behavior	Biological Process	IMP (12920299)
GO:0007517	muscle development	Biological Process	IMP (15170223)
GO:0006814	sodium ion transport	Biological Process	NAS (9828131)
GO:0006811	ion transport	Biological Process	IEA