ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sorbs3

Full Name:

sorbin and SH3 domain containing 3

Alias:

SH3P3|Sh3d4|vinexin-g

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 D2|14 34.5 cM

Physical Location:

70580274-70607443 on NC_000080.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10174 Symbol (Name): SORBS3 (sorbin and SH3 domain containing 3)

Ortholog Status:

The human GeneID 10174 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws5/Alcw7	Chronic Alcohol Withdrawal	14		24-48 (cM)	4.2	6.00E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011366.2	NP_035496.1	NC_000080.5 range: 70580274..70607443, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005925	focal adhesion	Cellular Component	IDA (9885244)
GO:0030054	cell junction	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IDA (9885244\|15734736\|15836771)
GO:0005634	nucleus	Cellular Component	IDA (9885244\|15734736)
GO:0005515	protein binding	Molecular Function	IPI (15836771)
GO:0005515	protein binding	Molecular Function	IDA (9630982)
GO:0008134	transcription factor binding	Molecular Function	IPI (15734736)
GO:0031589	cell-substrate adhesion	Biological Process	IDA (9885244)
GO:0043410	positive regulation of MAPKKK cascade	Biological Process	IDA (15836771)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15734736)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IMP (15734736)
GO:0043410	positive regulation of MAPKKK cascade	Biological Process	IMP (15836771)