ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

2064

Symbol:

ERBB2

Full Name:

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Alias:

CD340|HER-2|HER-2/neu|HER2|NEU|NGL|TKR1|c-erb B2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q11.2-q12|17q21.1

Physical Location:

35097918-35138440 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

ERBB2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001005862.1	NP_001005862.1	NC_000017.9 range: 35097918..35138440
NM_004448.2	NP_004439.2	NC_000017.9 range: 35097918..35138440

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	NAS (15609325)
GO:0043235	receptor complex	Cellular Component	TAS (7556068)
GO:0043235	receptor complex	Cellular Component	IDA (7514177)
GO:0016323	basolateral plasma membrane	Cellular Component	IDA (12646923)
GO:0005886	plasma membrane	Cellular Component	NAS (12000754)
GO:0005576	extracellular region	Cellular Component	IDA (10485918)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0019838	growth factor binding	Molecular Function	IDA (7514177)
GO:0042802	identical protein binding	Molecular Function	IPI (16843263)
GO:0043125	ErbB-3 class receptor binding	Molecular Function	TAS (9590694)
GO:0046982	protein heterodimerization activity	Molecular Function	IDA (10572067)
GO:0046982	protein heterodimerization activity	Molecular Function	NAS (15504738)
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0051536	iron-sulfur cluster binding	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	IDA (10485918)
GO:0004716	receptor signaling protein tyrosine kinase activity	Molecular Function	TAS (10851066)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004888	transmembrane receptor activity	Molecular Function	IDA (7514177)
GO:0005006	epidermal growth factor receptor activity	Molecular Function	NAS (15504738)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0050679	positive regulation of epithelial cell proliferation	Biological Process	IDA (10572067)
GO:0048015	phosphoinositide-mediated signaling	Biological Process	NAS (15504738)
GO:0008283	cell proliferation	Biological Process	TAS (10851066)
GO:0007399	nervous system development	Biological Process	TAS (15504738)
GO:0046777	protein amino acid autophosphorylation	Biological Process	IDA (7556068)
GO:0045785	positive regulation of cell adhesion	Biological Process	IDA (7556068)
GO:0045765	regulation of angiogenesis	Biological Process	NAS (15609325)
GO:0043406	positive regulation of MAP kinase activity	Biological Process	IDA (10572067)
GO:0014065	phosphoinositide 3-kinase cascade	Biological Process	IDA (7556068)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	NAS (15609325)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IDA (10485918)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0042060	wound healing	Biological Process	IDA (12646923)
GO:0030879	mammary gland development	Biological Process	TAS (15504738)
GO:0007507	heart development	Biological Process	TAS (15504738)