ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ERBB4

Full Name:

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Alias:

HER4|MGC138404|p180erbB4

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33.3-q34

Physical Location:

211948686-213111596 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 13869 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

ERBB4

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016323	basolateral plasma membrane	Cellular Component	IDA (12646923)
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (8383326)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0046982	protein heterodimerization activity	Molecular Function	IDA (10572067)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (9419975\|10572067\|11867753)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	TAS (8383326)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	TAS (8383326)
GO:0008283	cell proliferation	Biological Process	TAS (8383326)
GO:0007165	signal transduction	Biological Process	IDA (10572067)