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Gene Information
Gene ID:20674
Symbol:Sox2
Full Name:SRY-box containing gene 2
Alias:Sox-2|lcc|ysb
Organism:Mus musculus (Mouse)
Chromosome:3
Genetic Location:3 A2-B|3 15.0 cM
Physical Location:34548926-34551382 on NC_000069.5
Gene Type:protein-coding
Human Ortholog:GeneID: 6657    Symbol (Name): SOX2 (SRY (sex determining region Y)-box 2)
Ortholog Status:The human GeneID 6657 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X94127
Fold Change:-2.6, -2.0, -1.9, -1
Note:4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2
Dataset Information
Name:15002731
Method:Microarray
Tissue:Whole brain
Phenotype:Acute ethanol response
Publication:Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011443.3NP_035573.3NC_000069.5 range: 34548926..34551382
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISO
GO:0005737cytoplasmCellular ComponentIDA (12514105)
GO:0005634nucleusCellular ComponentIDA (9512512|12514105|17522155)
GO:0005634nucleusCellular ComponentIC (12665572)
GO:0003700transcription factor activityMolecular FunctionIDA (7628452|9669521|12665572)
GO:0005515protein bindingMolecular FunctionIPI (7590241|15863505)
GO:0003677DNA bindingMolecular FunctionIGI (15863505)
GO:0003677DNA bindingMolecular FunctionIDA (8625802|12665572|15082719)
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (7628452|9649510|9669521)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIGI (7590241|15863505)
GO:0046148pigment biosynthetic processBiological ProcessIMP (12036291)
GO:0048568embryonic organ developmentBiological ProcessIMP (17522155)
GO:0048646anatomical structure formationBiological ProcessIMP (9851841|17522155)
GO:0048663neuron fate commitmentBiological ProcessIMP (17015430)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIGI (9649510)
GO:0050910detection of mechanical stimulus involved in sensory perception of soundBiological ProcessIMP (15846349)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (7628452)
GO:0043586tongue developmentBiological ProcessIMP (17015430)
GO:0042472inner ear morphogenesisBiological ProcessIMP (15846349)
GO:0019827stem cell maintenanceBiological ProcessIMP (16767105)
GO:0007605sensory perception of soundBiological ProcessIMP (12036291)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIDA (12665572)
GO:0006350transcriptionBiological ProcessIEA
GO:0001708cell fate specificationBiological ProcessIMP (12514105)
GO:0050973detection of mechanical stimulus involved in equilibrioceptionBiological ProcessIMP (15846349)
Other Database Cross Links
NCBI Entrez Gene:20674
MGI:
Ensembl:ENSMUSG00000074637
dbSNP:Sox2
AceView:Sox2