ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

2068

Symbol:

ERCC2

Full Name:

excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)

Alias:

COFS2|EM9|MGC102762|MGC126218|MGC126219|TTD|XPD

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19q13.3

Physical Location:

50546685-50565668 on NC_000019.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

ERCC2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000400.2	NP_000391.1	NC_000019.8 range: 50546685..50565668, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005675	holo TFIIH complex	Cellular Component	TAS (7663514)
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	Cellular Component	IDA (8692842\|11445587)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005654	nucleoplasm	Cellular Component	EXP (1939271\|2449431\|8946909\|9512541\|9582279\|9790902\|10214908\|11313499\|12393749\|12646563)
GO:0016563	transcription activator activity	Molecular Function	IDA (8692842)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Molecular Function	IEA
GO:0043139	5'-3' DNA helicase activity	Molecular Function	IDA (8663148\|11445587)
GO:0047485	protein N-terminus binding	Molecular Function	IPI (8652557)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0008022	protein C-terminus binding	Molecular Function	IPI (10801852)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	IEA
GO:0033683	nucleotide-excision repair, DNA incision	Biological Process	IMP (8692841)
GO:0035315	hair cell differentiation	Biological Process	IMP (11335038)
GO:0009650	UV protection	Biological Process	IGI (2835663)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (8692841)
GO:0007605	sensory perception of sound	Biological Process	IEA
GO:0006979	response to oxidative stress	Biological Process	IMP (17614221)
GO:0000718	nucleotide-excision repair, DNA damage removal	Biological Process	EXP (10583946)
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Biological Process	IEA
GO:0006283	transcription-coupled nucleotide-excision repair	Biological Process	IDA (8663148)
GO:0006289	nucleotide-excision repair	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	EXP (8946909)
GO:0006368	RNA elongation from RNA polymerase II promoter	Biological Process	EXP (9405375)
GO:0006917	induction of apoptosis	Biological Process	IMP (8675009)
GO:0000075	cell cycle checkpoint	Biological Process	IMP (17088560)