ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

20682

Symbol:

Sox9

Full Name:

SRY-box containing gene 9

Alias:

2010306G03Rik|AV220920|KIAA4243|mKIAA4243

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 E2|11 69.5 cM

Physical Location:

112643537-112649062 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6662 Symbol (Name): SOX9 (SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal))

Ortholog Status:

The human GeneID 6662 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI852411
Fold Change:		NC, NC, -1.9, -1.6
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011448.4	NP_035578.3	NC_000077.5 range: 112643537..112649062

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12133909\|12915303\|15229180\|15585950\|15590666\|15944199\|16207837)
GO:0016563	transcription activator activity	Molecular Function	IDA (15778499)
GO:0005515	protein binding	Molecular Function	IPI (12381733\|12732652)
GO:0003677	DNA binding	Molecular Function	IDA (15590666)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (15800003)
GO:0045165	cell fate commitment	Biological Process	IGI (15893981)
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA (15778499)
GO:0042981	regulation of apoptosis	Biological Process	IMP (16085486)
GO:0042127	regulation of cell proliferation	Biological Process	IMP (16085486)
GO:0030238	male sex determination	Biological Process	IGI (16700629)
GO:0030154	cell differentiation	Biological Process	IMP (12414734)
GO:0019100	male germ-line sex determination	Biological Process	IMP (11431689\|16207837)
GO:0001502	cartilage condensation	Biological Process	IMP (10319868\|12414734)
GO:0014032	neural crest cell development	Biological Process	IMP (15691760)
GO:0008584	male gonad development	Biological Process	IMP (11431689)
GO:0007507	heart development	Biological Process	IMP (15096597)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	TAS (10319868)
GO:0006350	transcription	Biological Process	IEA
GO:0001942	hair follicle development	Biological Process	IMP (16085486)
GO:0001837	epithelial to mesenchymal transition	Biological Process	IMP (15096597)
GO:0001708	cell fate specification	Biological Process	IMP (12842915)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (12381733\|12732652\|15590666\|17644814)