ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ERCC4

Full Name:

excision repair cross-complementing rodent repair deficiency, complementation group 4

Alias:

RAD1|XPF

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

16p13.3-p13.11

Physical Location:

13921523-13949704 on NC_000016.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

ERCC4

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005236.2	NP_005227.1	NC_000016.8 range: 13921523..13949704

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000109	nucleotide-excision repair complex	Cellular Component	IDA (10413517)
GO:0005654	nucleoplasm	Cellular Component	EXP (10214908\|11313499)
GO:0005634	nucleus	Cellular Component	IDA (12571280)
GO:0000784	nuclear chromosome, telomeric region	Cellular Component	IDA (14690602)
GO:0047485	protein N-terminus binding	Molecular Function	IPI (14734547)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0008022	protein C-terminus binding	Molecular Function	IPI (9722633)
GO:0004520	endodeoxyribonuclease activity	Molecular Function	IDA (8797827)
GO:0004520	endodeoxyribonuclease activity	Molecular Function	IDA (10413517\|14734547)
GO:0003697	single-stranded DNA binding	Molecular Function	IDA (10413517)
GO:0003684	damaged DNA binding	Molecular Function	IMP (11790111)
GO:0009411	response to UV	Biological Process	IMP (16678501)
GO:0032205	negative regulation of telomere maintenance	Biological Process	IMP (17055345)
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	Biological Process	IMP (11790111\|14728600)
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion	Biological Process	IMP (11790111)
GO:0000718	nucleotide-excision repair, DNA damage removal	Biological Process	EXP (10583946)
GO:0000724	double-strand break repair via homologous recombination	Biological Process	IMP (14728600)