ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tcea1

Full Name:

transcription elongation factor A (SII) 1

Alias:

MGC103154|S-II

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 A1

Physical Location:

4847895-4887985 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6917 Symbol (Name): TCEA1 (transcription elongation factor A (SII), 1)

Ortholog Status:

The human GeneID 6917 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Tcea1
Fold Change:		1.81
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011541.3	NP_035671.1	NC_000067.5 range: 4847895..4887985

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	IDA (12761297)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0030528	transcription regulator activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12761297)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	IEA
GO:0003711	transcription elongation regulator activity	Molecular Function	IEA
GO:0003746	translation elongation factor activity	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0030218	erythrocyte differentiation	Biological Process	IMP (16581793)
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA (12761297)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (16581793)
GO:0006354	RNA elongation	Biological Process	IEA