ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nudt15

Full Name:

nudix (nucleoside diphosphate linked moiety X)-type motif 15

Alias:

6530403O17|A730068G11Rik|MTH2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 D3

Physical Location:

73919670-73948048 on NC_000080.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55270 Symbol (Name): NUDT15 (nudix (nucleoside diphosphate linked moiety X)-type motif 15)

Ortholog Status:

The human GeneID 55270 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15668661
Method:		Microarray
Tissue:		Fetal brain
Phenotype:		Ethanol response
Publication:		Hard et al. J Lab Clin Med. (2005) Gene-expression analysis after alcohol exposure in the developing mouse. PubMed
Summary:		Exposure to alcohol in the embryonic mouse can lead to structural and neurophysiologic changes. Here we investigate ethanol-induced alterations in gene expression in the fetal brain. Using complementary-DNA microarrays, we identified 25 genes that were down-regulated by prenatal ethanol exposure on days 7 and 9 of gestation. None were found to be up-regulated.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_172527.2	NP_766115.1	NC_000080.5 range: 73919670..73948048, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0008413	8-oxo-7,8-dihydroguanine triphosphatase activity	Molecular Function	IDA (12767940)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0000302	response to reactive oxygen species	Biological Process	IDA (12767940)
GO:0009217	purine deoxyribonucleoside triphosphate catabolic process	Biological Process	IDA (12767940)