ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

2149

Symbol:

F2R

Full Name:

coagulation factor II (thrombin) receptor

Alias:

CF2R|HTR|PAR1|TR

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q13

Physical Location:

76047541-76067053 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D5S647

66282906

Region:		66282906-76193808
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001992.3	NP_001983.2	NC_000005.8 range: 76047541..76067053

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031094	platelet dense tubular network	Cellular Component	IDA (9038223)
GO:0005901	caveola	Cellular Component	IDA (17848177)
GO:0005794	Golgi apparatus	Cellular Component	TAS (7961693)
GO:0005886	plasma membrane	Cellular Component	EXP (1851174\|10477691)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (1672265)
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0015057	thrombin receptor activity	Molecular Function	TAS (9038223)
GO:0005102	receptor binding	Molecular Function	IPI (1672265)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0030168	platelet activation	Biological Process	IDA (9038223)
GO:0030194	positive regulation of blood coagulation	Biological Process	IDA (9038223)
GO:0030335	positive regulation of cell migration	Biological Process	IMP (9701242)
GO:0046427	positive regulation of JAK-STAT cascade	Biological Process	IDA (10692450)
GO:0032967	positive regulation of collagen biosynthetic process	Biological Process	IDA (9639571)
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IEP (12761501)
GO:0043410	positive regulation of MAPKKK cascade	Biological Process	IDA (17848177)
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA (17848177)
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS (9701242)
GO:0002248	connective tissue replacement during inflammatory response	Biological Process	IDA (9639571)
GO:0006919	caspase activation	Biological Process	IDA (10692450)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007260	tyrosine phosphorylation of STAT protein	Biological Process	IDA (10692450)
GO:0007262	STAT protein nuclear translocation	Biological Process	IDA (10692450)
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA (10692450)
GO:0009611	response to wounding	Biological Process	IDA (9639571)
GO:0051209	release of sequestered calcium ion into cytosol	Biological Process	IDA (1672265)