ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

F2RL2

Full Name:

coagulation factor II (thrombin) receptor-like 2

Alias:

PAR3

Organism:

Homo sapiens (Human)

Chromosome:

5

Genetic Location:

5q13

Physical Location:

75947062-75954995 on NC_000005.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D5S647

66282906

Region:		66282906-76193808
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004101.2	NP_004092.1	NC_000005.8 range: 75947062..75954995, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9087410)
GO:0005886	plasma membrane	Cellular Component	TAS (9087410)
GO:0005886	plasma membrane	Cellular Component	EXP (1851174\|10477691)
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004435	phosphoinositide phospholipase C activity	Molecular Function	TAS (9087410)
GO:0015057	thrombin receptor activity	Molecular Function	TAS (9087410)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007596	blood coagulation	Biological Process	TAS (9087410)
GO:0009611	response to wounding	Biological Process	TAS (9087410)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000164220

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: