ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Prdx2

Full Name:

peroxiredoxin 2

Alias:

AL022839|Band-8|NkefB|PRP|PrxII|TDX1|TPx|TPx-B|TR|TSA|Tdpx1|Torin

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 C3|8 36.0 cM

Physical Location:

87493520-87498706 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7001 Symbol (Name): PRDX2 (peroxiredoxin 2)

Ortholog Status:

The human GeneID 7001 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Prdx2

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws3/Alcw6	Chronic Alcohol Withdrawal	8		16-43 (cM)	3.5	0.0003	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011563.5	NP_035693.3	NC_000074.5 range: 87493520..87498706

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004601	peroxidase activity	Molecular Function	TAS (9115640)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016209	antioxidant activity	Molecular Function	IEA
GO:0008430	selenium binding	Molecular Function	TAS (9792801)
GO:0008379	thioredoxin peroxidase activity	Molecular Function	TAS (9714804)
GO:0008379	thioredoxin peroxidase activity	Molecular Function	ISS (9115640)
GO:0051920	peroxiredoxin activity	Molecular Function	IEA
GO:0006979	response to oxidative stress	Biological Process	TAS (9115640)
GO:0006916	anti-apoptosis	Biological Process	IMP (15259009)
GO:0006916	anti-apoptosis	Biological Process	IDA (9115640)
GO:0006800	oxygen and reactive oxygen species metabolic process	Biological Process	TAS (9714804\|9792801)
GO:0042098	T cell proliferation	Biological Process	IMP (15259009)
GO:0042743	hydrogen peroxide metabolic process	Biological Process	IMP (15259009)
GO:0048538	thymus development	Biological Process	IMP (15259009)
GO:0048872	homeostasis of number of cells	Biological Process	IMP (15259009)