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Gene Information
Gene ID:216873
Symbol:Spag7
Full Name:sperm associated antigen 7
Alias:5730443G10|ACRP|FSA-1|Fsa1l|MGC67704
Organism:Mus musculus (Mouse)
Chromosome:11
Genetic Location:11 B4|11 42.0 cM
Physical Location:70477291-70482794 on NC_000077.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9552    Symbol (Name): SPAG7 (sperm associated antigen 7)
Ortholog Status:The human GeneID 9552 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Spag7
Fold Change:1.37
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Lore4Alcohol-induced Loss of Righting Reflex11 36-42 (cM)6.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_172561.2NP_766149.1NC_000077.5 range: 70477291..70482794, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0003676nucleic acid bindingMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:216873
MGI:
Ensembl:ENSMUSG00000018287
dbSNP:Spag7
AceView:Spag7