ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nr1d1

Full Name:

nuclear receptor subfamily 1, group D, member 1

Alias:

A530070C09Rik|R75201

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 D

Physical Location:

98629248-98636555 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9572 Symbol (Name): NR1D1 (nuclear receptor subfamily 1, group D, member 1)

Ortholog Status:

The human GeneID 9572 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nr1d1
Fold Change:		0.59
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_145434.3	NP_663409.2	NC_000077.5 range: 98629248..98636555, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12150932)
GO:0003677	DNA binding	Molecular Function	IDA (7838158)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004879	ligand-dependent nuclear receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0003707	steroid hormone receptor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IDA (7838158\|12150932)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (7838158)
GO:0007623	circadian rhythm	Biological Process	IDA (12150932)
GO:0006350	transcription	Biological Process	IEA