ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Trib2

Full Name:

tribbles homolog 2 (Drosophila)

Alias:

AW319517|TRB-2|TRB2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

12 A1.1

Physical Location:

15798532-15823590 on NC_000078.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 28951 Symbol (Name): TRIB2 (tribbles homolog 2 (Drosophila))

Ortholog Status:

The human GeneID 28951 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI842510
Fold Change:		-1.4, -1.3, -1.5, -1
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_144551.5	NP_653134.2	NC_000078.5 range: 15798532..15823590, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0004860	protein kinase inhibitor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17097562)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA