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Gene Information
Gene ID:2181
Symbol:ACSL3
Full Name:acyl-CoA synthetase long-chain family member 3
Alias:ACS3|FACL3|PRO2194
Organism:Homo sapiens (Human)
Chromosome:2
Genetic Location:2q34-q35
Physical Location:223433975-223516362 on NC_000002.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:N76698
Fold Change:0.68
P Value:0.01
Tissue:Nucleus accumbens
Dataset Information
Name:15816859
Method:Microarray
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004457.3NP_004448.2NC_000002.10 range: 223433975..223516362
NM_203372.1NP_976251.1NC_000002.10 range: 223433975..223516362
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005792microsomeCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIEA
GO:0005741mitochondrial outer membraneCellular ComponentIEA
GO:0005777peroxisomeCellular ComponentIEA
GO:0005778peroxisomal membraneCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17220478)
GO:0004467long-chain-fatty-acid-CoA ligase activityMolecular FunctionIEA
GO:0004321fatty-acyl-CoA synthase activityMolecular FunctionTAS (8663269)
GO:0016874ligase activityMolecular FunctionIEA
GO:0006629lipid metabolic processBiological ProcessIEA
GO:0006631fatty acid metabolic processBiological ProcessIEA
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:2181
HGNC:3570
Ensembl:ENSG00000123983
MIM:602371
HPRD:03845
HuGE Navigator:2181
dbSNP:ACSL3
GeneCard:ACSL3
AceView:ACSL3