ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

21813

Symbol:

Tgfbr2

Full Name:

transforming growth factor, beta receptor II

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 F3|9 69.0 cM

Physical Location:

115996824-116084406 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7048 Symbol (Name): TGFBR2 (transforming growth factor, beta receptor II (70/80kDa))

Ortholog Status:

The human GeneID 7048 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Etact2	Alcohol Stimulated Activity	9	61	51-71 (cM)	3.6	4.30E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009371.2	NP_033397.2	NC_000075.5 range: 115996824..116084406, complement
NM_029575.2	NP_083851.2	NC_000075.5 range: 115996824..116084406, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0009897	external side of plasma membrane	Cellular Component	IDA (16973387)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004702	receptor signaling protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0032147	activation of protein kinase activity	Biological Process	IDA (16806156)
GO:0042127	regulation of cell proliferation	Biological Process	IMP (12975342)
GO:0043011	myeloid dendritic cell differentiation	Biological Process	IMP (17938236)
GO:0048701	embryonic cranial skeleton morphogenesis	Biological Process	IMP (16806156)
GO:0007507	heart development	Biological Process	IMP (16332365\|17078885)
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (11893733)
GO:0002666	positive regulation of T cell tolerance induction	Biological Process	IMP (16973387)
GO:0002663	positive regulation of B cell tolerance induction	Biological Process	IMP (16973387)
GO:0002651	positive regulation of tolerance induction to self antigen	Biological Process	IMP (16973387)
GO:0001569	patterning of blood vessels	Biological Process	IMP (17078885)
GO:0051138	positive regulation of NK T cell differentiation	Biological Process	IMP (16973387)