ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tle1

Full Name:

transducin-like enhancer of split 1, homolog of Drosophila E(spl)

Alias:

C230057C06Rik|Grg1

Organism:

Mus musculus (Mouse)

Chromosome:

Physical Location:

71778175-71861890 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7088 Symbol (Name): TLE1 (transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila))

Ortholog Status:

The human GeneID 7088 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		16783646
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Alcohol preference, acute functional tolerance
Publication:		Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:		Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011599.4	NP_035729.3	NC_000070.5 range: 71778175..71861890, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (12359720)
GO:0005667	transcription factor complex	Cellular Component	IDA (15528197)
GO:0003682	chromatin binding	Molecular Function	IDA (16002402)
GO:0003714	transcription corepressor activity	Molecular Function	IDA (15528197)
GO:0005515	protein binding	Molecular Function	IPI (12359720\|15528197)
GO:0016055	Wnt receptor signaling pathway	Biological Process	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15528197)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (15528197)
GO:0006350	transcription	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (12359720\|15528197)
GO:0045449	regulation of transcription	Biological Process	IEA