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Gene Information
Gene ID:21885
Full Name:transducin-like enhancer of split 1, homolog of Drosophila E(spl)
Organism:Mus musculus (Mouse)
Physical Location:71778175-71861890 on NC_000070.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7088    Symbol (Name): TLE1 (transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila))
Ortholog Status:The human GeneID 7088 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Tle1
Fold Change:3.19
P Value:0.077
Note:acute functional tolerance
Dataset Information
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Alcohol preference, acute functional tolerance
Publication:Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011599.4NP_035729.3NC_000070.5 range: 71778175..71861890, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (12359720)
GO:0005667transcription factor complexCellular ComponentIDA (15528197)
GO:0003682chromatin bindingMolecular FunctionIDA (16002402)
GO:0003714transcription corepressor activityMolecular FunctionIDA (15528197)
GO:0005515protein bindingMolecular FunctionIPI (12359720|15528197)
GO:0016055Wnt receptor signaling pathwayBiological ProcessIEA
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessIGI (15528197)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIDA (15528197)
GO:0006350transcriptionBiological ProcessIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (12359720|15528197)
GO:0045449regulation of transcriptionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:21885