ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tuba1a

Full Name:

tubulin, alpha 1A

Alias:

MGC102097|MGC102098|MGC102099|Tuba-1|Tuba1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 F1|15 60.4 cM

Physical Location:

98780277-98783931 on NC_000081.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7846 Symbol (Name): TUBA1A (tubulin, alpha 1a)

Ortholog Status:

The human GeneID 7846 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Tuba1
Fold Change:		1.88
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011653.2	NP_035783.1	NC_000081.5 range: 98780277..98783931, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005874	microtubule	Cellular Component	IEA
GO:0043234	protein complex	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	IEA
GO:0005198	structural molecule activity	Molecular Function	RCA (12466851)
GO:0005525	GTP binding	Molecular Function	RCA (12466851)
GO:0007017	microtubule-based process	Biological Process	IEA
GO:0007018	microtubule-based movement	Biological Process	RCA (12466851)
GO:0051258	protein polymerization	Biological Process	IEA