ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Uba3

Full Name:

ubiquitin-like modifier activating enzyme 3

Alias:

A830034N06Rik|AI256736|AI848246|AW546539|Ube1c

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 D3

Physical Location:

97134021-97155336 on NC_000072.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9039 Symbol (Name): UBA3 (ubiquitin-like modifier activating enzyme 3)

Ortholog Status:

The human GeneID 9039 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ube1c
Fold Change:		1.3
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011666.2	NP_035796.2	NC_000072.5 range: 97134021..97155336, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0019781	NEDD8 activating enzyme activity	Molecular Function	TAS (11696557)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0008641	small protein activating enzyme activity	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0007113	endomitotic cell cycle	Biological Process	IMP (11696557)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0006464	protein modification process	Biological Process	IEA
GO:0000278	mitotic cell cycle	Biological Process	IMP (11696557)
GO:0051726	regulation of cell cycle	Biological Process	IMP (11696557)