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Gene Information
Gene ID:22200
Full Name:ubiquitin-like modifier activating enzyme 3
Organism:Mus musculus (Mouse)
Genetic Location:6 D3
Physical Location:97134021-97155336 on NC_000072.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9039    Symbol (Name): UBA3 (ubiquitin-like modifier activating enzyme 3)
Ortholog Status:The human GeneID 9039 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ube1c
Fold Change:1.3
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011666.2NP_035796.2NC_000072.5 range: 97134021..97155336, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0019781NEDD8 activating enzyme activityMolecular FunctionTAS (11696557)
GO:0003824catalytic activityMolecular FunctionIEA
GO:0005488bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0016874ligase activityMolecular FunctionIEA
GO:0008641small protein activating enzyme activityMolecular FunctionIEA
GO:0008152metabolic processBiological ProcessIEA
GO:0007113endomitotic cell cycleBiological ProcessIMP (11696557)
GO:0007049cell cycleBiological ProcessIEA
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0006464protein modification processBiological ProcessIEA
GO:0000278mitotic cell cycleBiological ProcessIMP (11696557)
GO:0051726regulation of cell cycleBiological ProcessIMP (11696557)
Other Database Cross Links
NCBI Entrez Gene:22200