ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FDFT1

Full Name:

farnesyl-diphosphate farnesyltransferase 1

Alias:

DGPT|ERG9|SQS|SS

Organism:

Homo sapiens (Human)

Chromosome:

8

Genetic Location:

8p23.1-p22

Physical Location:

11697598-11734226 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D8S550

10918926

Region:		8918926-12918926
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004462.3	NP_004453.3	NC_000008.9 range: 11697598..11734226

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	TAS (8474436)
GO:0016020	membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	EXP (10896663)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0004310	farnesyl-diphosphate farnesyltransferase activity	Molecular Function	IEA
GO:0004310	farnesyl-diphosphate farnesyltransferase activity	Molecular Function	EXP (10896663)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006695	cholesterol biosynthetic process	Biological Process	IEA
GO:0008299	isoprenoid biosynthetic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000079459

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: