ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Usf1

Full Name:

upstream transcription factor 1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H|1 93.3 cM

Physical Location:

173341811-173348873 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7391 Symbol (Name): USF1 (upstream transcription factor 1)

Ortholog Status:

The human GeneID 7391 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Usf1
Fold Change:		0.74
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcw1	Acute Alcohol Withdrawal	1	96	172.3-176.5 (Mb)	5.6	3.00E-07	Significant	PARC
Calw1/Alcdp1	Chronic Alcohol Withdrawal	1	96	89-106.3 (cM)	7.6	2.00E-09	Significant	PARC
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009480.2	NP_033506.1	NC_000067.5 range: 173341811..173348873

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005667	transcription factor complex	Cellular Component	IC (15466854)
GO:0003677	DNA binding	Molecular Function	IDA (15466854)
GO:0003700	transcription factor activity	Molecular Function	IDA (15466854)
GO:0030528	transcription regulator activity	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA (15466854)