ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

22427

Symbol:

Wrn

Full Name:

Werner syndrome homolog (human)

Alias:

AI846146

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 A4|8 20.0 cM

Physical Location:

34344844-34495973 on NC_000074.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7486 Symbol (Name): WRN (Werner syndrome)

Ortholog Status:

The human GeneID 7486 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws3/Alcw6	Chronic Alcohol Withdrawal	8		16-43 (cM)	3.5	0.0003	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011721.4	NP_035851.3	NC_000074.5 range: 34344844..34495973, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	ISO
GO:0005634	nucleus	Cellular Component	IDA (9789047)
GO:0005654	nucleoplasm	Cellular Component	IDA (11420665)
GO:0005730	nucleolus	Cellular Component	IDA (11420665)
GO:0005730	nucleolus	Cellular Component	ISO
GO:0005622	intracellular	Cellular Component	IEA
GO:0008026	ATP-dependent helicase activity	Molecular Function	IEA
GO:0008408	3'-5' exonuclease activity	Molecular Function	IDA (10871373)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0008408	3'-5' exonuclease activity	Molecular Function	ISO
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003678	DNA helicase activity	Molecular Function	ISO
GO:0004386	helicase activity	Molecular Function	IEA
GO:0004527	exonuclease activity	Molecular Function	ISO
GO:0005515	protein binding	Molecular Function	IPI (11301316)
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0040009	regulation of growth rate	Biological Process	IMP (12707040)
GO:0000723	telomere maintenance	Biological Process	IGI (15235603\|15367665)
GO:0010259	multicellular organismal aging	Biological Process	IGI (15235603)
GO:0000723	telomere maintenance	Biological Process	IMP (12707040)
GO:0001302	replicative cell aging	Biological Process	IMP (10757812)
GO:0006310	DNA recombination	Biological Process	IEA
GO:0006260	DNA replication	Biological Process	IMP (9789047)
GO:0006259	DNA metabolic process	Biological Process	IMP (11756244\|12707040)
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Biological Process	IEA
GO:0042981	regulation of apoptosis	Biological Process	ISO