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Gene Information
Gene ID:22632
Full Name:YY1 transcription factor
Organism:Mus musculus (Mouse)
Genetic Location:12 F1|12 53.0 cM
Physical Location:110031520-110054841 on NC_000078.5
Gene Type:protein-coding
Human Ortholog:GeneID: 7528    Symbol (Name): YY1 (YY1 transcription factor)
Ortholog Status:The human GeneID 7528 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Yy1
Fold Change:1.76
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009537.3NP_033563.2NC_000078.5 range: 110031520..110054841
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005667transcription factor complexCellular ComponentIDA (11861914)
GO:0031519PcG protein complexCellular ComponentIDA (16624538)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0003676nucleic acid bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIDA (11861914)
GO:0003677DNA bindingMolecular FunctionIDA (12527199|15161869|15574595)
GO:0009952anterior/posterior pattern formationBiological ProcessIMP (16624538)
GO:0009952anterior/posterior pattern formationBiological ProcessIGI (16624538)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIDA (11861914)
GO:0006350transcriptionBiological ProcessIEA
GO:0048593camera-type eye morphogenesisBiological ProcessIGI (16624538)
Other Database Cross Links
NCBI Entrez Gene:22632