ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gpbar1

Full Name:

G protein-coupled bile acid receptor 1

Alias:

BG37|GPCR|GPR131|M-BAR|TGR5

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 C3|1 40.4 cM

Physical Location:

74325173-74326162 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 151306 Symbol (Name): GPBAR1 (G protein-coupled bile acid receptor 1)

Ortholog Status:

The human GeneID 151306 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws1/Alcw5	Chronic Alcohol Withdrawal	1		28-47 (cM)	6.5	3.00E-07	Significant	PARC
Lore1	Alcohol-induced Loss of Righting Reflex	1		36.9-41 (cM)	5.4		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_174985.1	NP_778150.1	NC_000067.5 range: 74325173..74326162

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	ISS (12419312)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA