ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MYO16

Full Name:

myosin XVI

Alias:

KIAA0865|MYR8|Myo16b

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

13q33.3

Physical Location:

108046500-108658355 on NC_000013.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene SNP Information

Association Dataset

Name:		16894614
Method:		Association
Publication:		Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Summary:		Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of 100k microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034).

Linkage Dataset

Marker

LOD

P value

Location (bp)

D13S1265

108126458

Region:		106126458-110126458
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_015011.1	NP_055826.1	NC_000013.9 range: 108046500..108658355

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA (17029291)
GO:0016459	myosin complex	Cellular Component	IEA
GO:0005654	nucleoplasm	Cellular Component	IDA (17029291)
GO:0005737	cytoplasm	Cellular Component	ISS (11588169)
GO:0005886	plasma membrane	Cellular Component	ISS (11588169\|17029291)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0051015	actin filament binding	Molecular Function	ISS (11588169)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0003774	motor activity	Molecular Function	IEA
GO:0021549	cerebellum development	Biological Process	ISS (11588169)
GO:0045749	negative regulation of S phase of mitotic cell cycle	Biological Process	ISS (17029291)
GO:0008285	negative regulation of cell proliferation	Biological Process	ISS (17029291)