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Gene Information
Gene ID:23039
Symbol:XPO7
Full Name:exportin 7
Alias:KIAA0745|RANBP16
Organism:Homo sapiens (Human)
Chromosome:8
Genetic Location:8p21
Physical Location:21833125-21920041 on NC_000008.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene SNP Information
SNPAbuser/Control RatioCluster
rs9314269      dbSNP0.8833
Association Dataset
Name:16894614
Method:Association
Publication:Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Summary:Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of 100k microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001100161.1NP_001093631.1NC_000008.9 range: 21833125..21920041
NM_001100162.1NP_001093632.1NC_000008.9 range: 21833125..21920041
NM_015024.4NP_055839.3NC_000008.9 range: 21833125..21920041
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (11071879)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005643nuclear poreCellular ComponentIEA
GO:0005643nuclear poreCellular ComponentIDA (11024021)
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (11071879)
GO:0005488bindingMolecular FunctionIEA
GO:0005049nuclear export signal receptor activityMolecular FunctionIDA (11024021)
GO:0008565protein transporter activityMolecular FunctionIEA
GO:0051028mRNA transportBiological ProcessIEA
GO:0006886intracellular protein transportBiological ProcessIEA
GO:0006611protein export from nucleusBiological ProcessIDA (11024021)
GO:0000059protein import into nucleus, dockingBiological ProcessIEA
GO:0065002intracellular protein transport across a membraneBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:23039
HGNC:14108
Ensembl:
MIM:606140
HPRD:05846
HuGE Navigator:23039
dbSNP:XPO7
GeneCard:XPO7
AceView:XPO7