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Gene Information
Gene ID:23047
Symbol:PDS5B
Full Name:PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
Alias:APRIN|AS3|CG008|FLJ23236|KIAA0979|RP1-267P19.1
Organism:Homo sapiens (Human)
Chromosome:13
Genetic Location:13q12.3
Physical Location:32058623-32250156 on NC_000013.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D13S171  32151912
Region:32151912-40979230
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_015032.2NP_055847.1NC_000013.9 range: 32058623..32250156
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0016020membraneCellular ComponentIEA
GO:0003677DNA bindingMolecular FunctionTAS (10215036)
GO:0005524ATP bindingMolecular FunctionTAS (10215036)
GO:0042802identical protein bindingMolecular FunctionIPI (15855230)
GO:0016758transferase activity, transferring hexosyl groupsMolecular FunctionIEA
GO:0008285negative regulation of cell proliferationBiological ProcessIDA (10963680)
GO:0007067mitosisBiological ProcessIEA
GO:0007064mitotic sister chromatid cohesionBiological ProcessIMP (15855230)
GO:0007049cell cycleBiological ProcessIEA
GO:0005975carbohydrate metabolic processBiological ProcessIEA
GO:0051301cell divisionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:23047
HGNC:20418
Ensembl:ENSG00000083642
MIM:605333
HPRD:05624
HuGE Navigator:23047
dbSNP:PDS5B
GeneCard:PDS5B
AceView:PDS5B