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Gene Information
Gene ID:2308
Full Name:forkhead box O1
Organism:Homo sapiens (Human)
Genetic Location:13q14.1
Physical Location:40027800-40138733 on NC_000013.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:FOXO1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D13S171  32151912
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002015.3NP_002006.2NC_000013.9 range: 40027800..40138733, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (11311120|12228231)
GO:0005737cytoplasmCellular ComponentIDA (11311120|12228231)
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (11353774)
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (12228231)
GO:0016563transcription activator activityMolecular FunctionIDA (7862145|10871843|12228231)
GO:0006916anti-apoptosisBiological ProcessIDA (10871843)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (10871843|12228231)
Other Database Cross Links
NCBI Entrez Gene:2308
HuGE Navigator:2308