| Gene Information |
| Gene ID: | | 23316 |
| Symbol: | | CUX2 |
| Full Name: | | cut-like homeobox 2 |
| Alias: | | CDP2|CUTL2 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 12 |
| Genetic Location: | | 12q24.11-q24.12 |
| Physical Location: | | 109956211-110272738 on NC_000012.10 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AB006631 | | Fold Change: | | 1.4, 1.4 | | Note: | | Differential Expression on the cDNA array (two fold changes are from two case groups) |
| | Dataset Information | | Name: | | 11141048 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed | | Summary: | | RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics. |
| | Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005634 | nucleus | Cellular Component | NAS | |
| GO:0003700 | transcription factor activity | Molecular Function | NAS | |
| GO:0043565 | sequence-specific DNA binding | Molecular Function | IEA | |
| GO:0006355 | regulation of transcription, DNA-dependent | Biological Process | NAS | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 23316 |
| HGNC: | | 19347 |
| Ensembl: | | |
| MIM: | | 610648 |
| HPRD: | | 10851 |
| HuGE Navigator: | | 23316 |
| dbSNP: | | CUX2 |
| GeneCard: | | CUX2 |
| AceView: | | CUX2 |
