ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GTPBP4

Full Name:

GTP binding protein 4

Alias:

CRFG|FLJ10686|FLJ10690|FLJ39774|NGB|NOG1

Organism:

Homo sapiens (Human)

Chromosome:

10

Genetic Location:

10p15-p14

Physical Location:

1024348-1053707 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D10S249

270791

Region:		1-2270791
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012341.2	NP_036473.2	NC_000010.9 range: 1024348..1053707

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (17210637)
GO:0005737	cytoplasm	Cellular Component	IDA (17210637)
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA (17210637)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	IDA (17210637)
GO:0005515	protein binding	Molecular Function	IPI (17210637\|17353931)
GO:0005525	GTP binding	Molecular Function	IDA (17210637)
GO:0005525	GTP binding	Molecular Function	IEA
GO:0033342	negative regulation of collagen binding	Biological Process	IMP (17210637)
GO:0042254	ribosome biogenesis and assembly	Biological Process	IEA
GO:0000079	regulation of cyclin-dependent protein kinase activity	Biological Process	IDA (17210637)
GO:0031397	negative regulation of protein ubiquitination	Biological Process	IDA (17210637)
GO:0030336	negative regulation of cell migration	Biological Process	IDA (17210637)
GO:0022408	negative regulation of cell-cell adhesion	Biological Process	IDA (17210637)
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (17210637)
GO:0008156	negative regulation of DNA replication	Biological Process	IMP (17210637)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0050821	protein stabilization	Biological Process	IDA (17210637)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000107937

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: