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Gene Information
Gene ID:23560
Symbol:GTPBP4
Full Name:GTP binding protein 4
Alias:CRFG|FLJ10686|FLJ10690|FLJ39774|NGB|NOG1
Organism:Homo sapiens (Human)
Chromosome:10
Genetic Location:10p15-p14
Physical Location:1024348-1053707 on NC_000010.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D10S249  270791
Region:1-2270791
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012341.2NP_036473.2NC_000010.9 range: 1024348..1053707
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (17210637)
GO:0005737cytoplasmCellular ComponentIDA (17210637)
GO:0048471perinuclear region of cytoplasmCellular ComponentIDA (17210637)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003924GTPase activityMolecular FunctionIDA (17210637)
GO:0005515protein bindingMolecular FunctionIPI (17210637|17353931)
GO:0005525GTP bindingMolecular FunctionIDA (17210637)
GO:0005525GTP bindingMolecular FunctionIEA
GO:0033342negative regulation of collagen bindingBiological ProcessIMP (17210637)
GO:0042254ribosome biogenesis and assemblyBiological ProcessIEA
GO:0000079regulation of cyclin-dependent protein kinase activityBiological ProcessIDA (17210637)
GO:0031397negative regulation of protein ubiquitinationBiological ProcessIDA (17210637)
GO:0030336negative regulation of cell migrationBiological ProcessIDA (17210637)
GO:0022408negative regulation of cell-cell adhesionBiological ProcessIDA (17210637)
GO:0008285negative regulation of cell proliferationBiological ProcessIMP (17210637)
GO:0008156negative regulation of DNA replicationBiological ProcessIMP (17210637)
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
GO:0050821protein stabilizationBiological ProcessIDA (17210637)
Other Database Cross Links
NCBI Entrez Gene:23560
HGNC:21535
Ensembl:ENSG00000107937
MIM:
HPRD:09976
HuGE Navigator:23560
dbSNP:GTPBP4
GeneCard:GTPBP4
AceView:GTPBP4