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Gene Information
Gene ID:23621
Symbol:BACE1
Full Name:beta-site APP-cleaving enzyme 1
Alias:ASP2|BACE|FLJ90568|HSPC104|KIAA1149
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11q23.2-q23.3
Physical Location:116661623-116692181 on NC_000011.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:BACE1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012104.3NP_036236.1NC_000011.8 range: 116661623..116692181, complement
NM_138971.2NP_620427.1NC_000011.8 range: 116661623..116692181, complement
NM_138972.2NP_620428.1NC_000011.8 range: 116661623..116692181, complement
NM_138973.2NP_620429.1NC_000011.8 range: 116661623..116692181, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005887integral to plasma membraneCellular ComponentTAS (10887202)
GO:0005768endosomeCellular ComponentIDA (10531052)
GO:0005768endosomeCellular ComponentISS
GO:0005794Golgi apparatusCellular ComponentIDA (10531052)
GO:0005794Golgi apparatusCellular ComponentISS
GO:0016020membraneCellular ComponentIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0009049aspartic-type signal peptidase activityMolecular FunctionIEA
GO:0004194pepsin A activityMolecular FunctionIEA
GO:0008798beta-aspartyl-peptidase activityMolecular FunctionTAS (10591214)
GO:0050435beta-amyloid metabolic processBiological ProcessIDA (15080893)
GO:0006509membrane protein ectodomain proteolysisBiological ProcessTAS (12354787)
GO:0006508proteolysisBiological ProcessIEA
GO:0006508proteolysisBiological ProcessIDA (10531052)
GO:0050435beta-amyloid metabolic processBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:23621
HGNC:933
Ensembl:ENSG00000186318
MIM:604252
HPRD:07255
HuGE Navigator:23621
dbSNP:BACE1
GeneCard:BACE1
AceView:BACE1