| Gene Information |
| Gene ID: | | 23786 |
| Symbol: | | BCL2L13 |
| Full Name: | | BCL2-like 13 (apoptosis facilitator) |
| Alias: | | BCL-RAMBO|MIL1 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 22 |
| Genetic Location: | | 22q11 |
| Physical Location: | | 16501484-16591990 on NC_000022.9 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Linkage Dataset | | Marker | LOD | P value | Location (bp) | |
| D22S420 | 2.04 | 0.0011 | 16239281 | | D22S1638 | 2.05 | 0.0011 | 17375064 | | Region: | | 16239281-17375064 | | Phenotype: | | TOLMX (tolerance/maximum drinking) | | Name: | | 17067344 | | Method: | | Linkage | | Publication: | | Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed | | Summary: | | A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005634 | nucleus | Cellular Component | IEA | |
| GO:0005739 | mitochondrion | Cellular Component | NAS (11262395) | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IDA (11262395) | |
| GO:0031966 | mitochondrial membrane | Cellular Component | IEA | |
| GO:0008656 | caspase activator activity | Molecular Function | NAS (11262395) | |
| GO:0006917 | induction of apoptosis | Biological Process | NAS (11262395) | |
| GO:0006919 | caspase activation | Biological Process | NAS (11262395) | |
| GO:0042981 | regulation of apoptosis | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 23786 |
| HGNC: | | 17164 |
| Ensembl: | | ENSG00000099968 |
| MIM: | | |
| HPRD: | | 09822 |
| HuGE Navigator: | | 23786 |
| dbSNP: | | BCL2L13 |
| GeneCard: | | BCL2L13 |
| AceView: | | BCL2L13 |
