ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gadd45g

Full Name:

growth arrest and DNA-damage-inducible 45 gamma

Alias:

AI327420|C86281|CR6|DDIT2|OIG37

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

13 A5-B

Physical Location:

51942061-51943843 on NC_000079.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10912 Symbol (Name): GADD45G (growth arrest and DNA-damage-inducible, gamma)

Ortholog Status:

The human GeneID 10912 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF055638
Fold Change:		1.5, 1.7, 1.6, 1.7
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011817.1	NP_035947.1	NC_000079.5 range: 51942061..51943843

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (12124778)
GO:0005515	protein binding	Molecular Function	IPI (11022036)
GO:0000186	activation of MAPKK activity	Biological Process	IDA (12213961)
GO:0045063	T-helper 1 cell differentiation	Biological Process	TAS (12213961)
GO:0042095	interferon-gamma biosynthetic process	Biological Process	TAS (12213961)
GO:0030154	cell differentiation	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IEA
GO:0006469	negative regulation of protein kinase activity	Biological Process	IDA (12124778)
GO:0051726	regulation of cell cycle	Biological Process	IDA (12124778)