ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hs2st1

Full Name:

heparan sulfate 2-O-sulfotransferase 1

Alias:

AW214369|Hs2st|mKIAA0448

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

3 H2

Physical Location:

144094073-144233101 on NC_000069.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9653 Symbol (Name): HS2ST1 (heparan sulfate 2-O-sulfotransferase 1)

Ortholog Status:

The human GeneID 9653 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Hs2st1

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011828.3	NP_035958.3	NC_000069.5 range: 144094073..144233101, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0004394	heparan sulfate 2-O-sulfotransferase activity	Molecular Function	IMP (11457822)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Biological Process	IMP (11457822)
GO:0030202	heparin metabolic process	Biological Process	IMP (11457822)