ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mmp17

Full Name:

matrix metallopeptidase 17

Alias:

MT4-MMP

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 G1.3|5 72.5 cM

Physical Location:

130090088-130114085 on NC_000071.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4326 Symbol (Name): MMP17 (matrix metallopeptidase 17 (membrane-inserted))

Ortholog Status:

The human GeneID 4326 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Mmp17

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011846.4	NP_035976.3	NC_000071.5 range: 130090088..130114085

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031225	anchored to membrane	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008237	metallopeptidase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0004222	metalloendopeptidase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	IEA