ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adamts4

Full Name:

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4

Alias:

3830423K05|ADAM-TS4|ADAMTS-2|ADMP-1|mKIAA0688

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H3|1 92.3 cM

Physical Location:

173180552-173190052 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9507 Symbol (Name): ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif, 4)

Ortholog Status:

The human GeneID 9507 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcw1	Acute Alcohol Withdrawal	1	96	172.3-176.5 (Mb)	5.6	3.00E-07	Significant	PARC
Calw1/Alcdp1	Chronic Alcohol Withdrawal	1	96	89-106.3 (cM)	7.6	2.00E-09	Significant	PARC
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_172845.2	NP_766433.1	NC_000067.5 range: 173180552..173190052

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	RCA (12466851)
GO:0031012	extracellular matrix	Cellular Component	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004222	metalloendopeptidase activity	Molecular Function	RCA (12466851)
GO:0016787	hydrolase activity	Molecular Function	RCA (12466851)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	RCA (12466851)
GO:0008237	metallopeptidase activity	Molecular Function	IDA (15192113)
GO:0007229	integrin-mediated signaling pathway	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	RCA (12466851)
GO:0006508	proteolysis	Biological Process	IDA (15192113)
GO:0001501	skeletal development	Biological Process	RCA (12466851)