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Gene Information
Gene ID:24534
Full Name:lactate dehydrogenase B
Organism:Rattus norvegicus (Rat)
Genetic Location:4q44
Physical Location:180061566-180079472 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3945    Symbol (Name): LDHB (lactate dehydrogenase B)
Ortholog Status:The human GeneID 3945 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ldhb
Fold Change:1.23
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012595.1NP_036727.1NC_005103.2 range: 180061566..180079472, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005625soluble fractionCellular ComponentIDA (17447164)
GO:0042802identical protein bindingMolecular FunctionIDA (7138505)
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0004457lactate dehydrogenase activityMolecular FunctionIDA (7138505)
GO:0005515protein bindingMolecular FunctionIPI (7138505)
GO:0005488bindingMolecular FunctionIEA
GO:0004459L-lactate dehydrogenase activityMolecular FunctionISS
GO:0004459L-lactate dehydrogenase activityMolecular FunctionIEA
GO:0004459L-lactate dehydrogenase activityMolecular FunctionIDA (17447164)
GO:0051287NAD bindingMolecular FunctionIDA (17447164)
GO:0006089lactate metabolic processBiological ProcessIDA (17447164)
GO:0008152metabolic processBiological ProcessIEA
GO:0019642anaerobic glycolysisBiological ProcessIEA
GO:0019674NAD metabolic processBiological ProcessIDA (17447164)
Other Database Cross Links
NCBI Entrez Gene:24534