ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ldhb

Full Name:

lactate dehydrogenase B

Alias:

Ldh2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q44

Physical Location:

180061566-180079472 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3945 Symbol (Name): LDHB (lactate dehydrogenase B)

Ortholog Status:

The human GeneID 3945 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012595.1	NP_036727.1	NC_005103.2 range: 180061566..180079472, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005625	soluble fraction	Cellular Component	IDA (17447164)
GO:0042802	identical protein binding	Molecular Function	IDA (7138505)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0004457	lactate dehydrogenase activity	Molecular Function	IDA (7138505)
GO:0005515	protein binding	Molecular Function	IPI (7138505)
GO:0005488	binding	Molecular Function	IEA
GO:0004459	L-lactate dehydrogenase activity	Molecular Function	ISS
GO:0004459	L-lactate dehydrogenase activity	Molecular Function	IEA
GO:0004459	L-lactate dehydrogenase activity	Molecular Function	IDA (17447164)
GO:0051287	NAD binding	Molecular Function	IDA (17447164)
GO:0006089	lactate metabolic process	Biological Process	IDA (17447164)
GO:0008152	metabolic process	Biological Process	IEA
GO:0019642	anaerobic glycolysis	Biological Process	IEA
GO:0019674	NAD metabolic process	Biological Process	IDA (17447164)