ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

24914

Symbol:

Lox

Full Name:

lysyl oxidase

Alias:

H-rev142|Rrg1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

18q11

Physical Location:

47893876-47906672 on NC_005117.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4015 Symbol (Name): LOX (lysyl oxidase)

Ortholog Status:

The human GeneID 4015 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Lox
Fold Change:		-1.22
Tissue:		Amygdala

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017061.2	NP_058757.1	NC_005117.2 range: 47893876..47906672, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IDA (10996848)
GO:0005581	collagen	Cellular Component	ISS
GO:0005581	collagen	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0005507	copper ion binding	Molecular Function	IMP (16432278)
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0004720	protein-lysine 6-oxidase activity	Molecular Function	ISS
GO:0004720	protein-lysine 6-oxidase activity	Molecular Function	IMP (16432278)
GO:0004720	protein-lysine 6-oxidase activity	Molecular Function	IEA
GO:0004720	protein-lysine 6-oxidase activity	Molecular Function	IDA (16804742)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0042493	response to drug	Biological Process	IEP (15816421)
GO:0042060	wound healing	Biological Process	IMP (16804742)
GO:0048251	elastic fiber assembly	Biological Process	IEA
GO:0048251	elastic fiber assembly	Biological Process	IMP (16432278)
GO:0001568	blood vessel development	Biological Process	IEA
GO:0048251	elastic fiber assembly	Biological Process	ISS
GO:0042060	wound healing	Biological Process	IEP (15816421)
GO:0030324	lung development	Biological Process	ISS
GO:0030324	lung development	Biological Process	IEA
GO:0030199	collagen fibril organization	Biological Process	ISS
GO:0030199	collagen fibril organization	Biological Process	IMP (16432278)
GO:0030199	collagen fibril organization	Biological Process	IEA
GO:0030199	collagen fibril organization	Biological Process	IDA (16804742)
GO:0009725	response to hormone stimulus	Biological Process	IDA (12488341)
GO:0001568	blood vessel development	Biological Process	ISS
GO:0048545	response to steroid hormone stimulus	Biological Process	IDA (12488341)