| Gene Information |
| Gene ID: | | 25165 |
| Symbol: | | Zfp386 |
| Full Name: | | zinc finger protein 386 (Kruppel-like) |
| Alias: | | Kzf1|Znf386 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 6 |
| Genetic Location: | | 6q33 |
| Physical Location: | | 143311747-143326392 on NC_005105.2 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Znf386 | | Fold Change: | | 1.22 | | Tissue: | | Caudate-putamen |
| | Dataset Information | | Name: | | 17517326 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed | | Summary: | | The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005622 | intracellular | Cellular Component | IEA | |
| GO:0005634 | nucleus | Cellular Component | IEA | |
| GO:0003677 | DNA binding | Molecular Function | IDA (9655926) | |
| GO:0003682 | chromatin binding | Molecular Function | ISS | |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | |
| GO:0016564 | transcription repressor activity | Molecular Function | IPI (9655926) | |
| GO:0046872 | metal ion binding | Molecular Function | IEA | |
| GO:0006355 | regulation of transcription, DNA-dependent | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 25165 |
| RGD: | | 2985 |
| Ensembl: | | ENSRNOG00000004268 |
| dbSNP: | | Zfp386 |
