| Gene Information |
| Gene ID: | | 25211 |
| Symbol: | | Lyz |
| Full Name: | | lysozyme |
| Alias: | | Lysz |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 7 |
| Genetic Location: | | 7q22 |
| Physical Location: | | 56607707-56613003 on NC_005106.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Lyz | | Fold Change: | | 2.11 | | Tissue: | | Accumbens |
| | Gene Information | | Original ID1: | | Lyz | | Fold Change: | | 1.81 | | Tissue: | | Amygdala |
| | Dataset Information | | Name: | | 17517326 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed | | Summary: | | The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0000137 | Golgi cis cisterna | Cellular Component | IDA (9208328) | |
| GO:0048237 | rough endoplasmic reticulum lumen | Cellular Component | IDA (9208328) | |
| GO:0030141 | secretory granule | Cellular Component | IDA (9208328) | |
| GO:0030140 | trans-Golgi network transport vesicle | Cellular Component | IDA (9208328) | |
| GO:0016022 | endoplasmic reticulum cisterna | Cellular Component | IDA (9208328) | |
| GO:0005902 | microvillus | Cellular Component | IDA (9208328) | |
| GO:0005795 | Golgi stack | Cellular Component | IDA (9208328) | |
| GO:0005737 | cytoplasm | Cellular Component | IDA (9208328) | |
| GO:0005625 | soluble fraction | Cellular Component | IDA (12965127) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0003796 | lysozyme activity | Molecular Function | IMP (2840982) | |
| GO:0003796 | lysozyme activity | Molecular Function | IDA (12965127) | |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | Molecular Function | IMP (2840982) | |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | Molecular Function | IEA | |
| GO:0003796 | lysozyme activity | Molecular Function | IEA | |
| GO:0042742 | defense response to bacterium | Biological Process | IEA | |
| GO:0050829 | defense response to Gram-negative bacterium | Biological Process | IMP (2840982) | |
| GO:0019835 | cytolysis | Biological Process | IEA | |
| GO:0016998 | cell wall catabolic process | Biological Process | IEA | |
| GO:0008152 | metabolic process | Biological Process | IEA | |
| GO:0050830 | defense response to Gram-positive bacterium | Biological Process | IMP (2840982) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 25211 |
| RGD: | | 3026 |
| Ensembl: | | ENSRNOG00000005825 |
| dbSNP: | | Lyz |
