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Gene Information
Gene ID:25288
Full Name:acyl-CoA synthetase long-chain family member 1
Organism:Rattus norvegicus (Rat)
Genetic Location:16q11
Physical Location:49036891-49081415 on NC_005115.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2180    Symbol (Name): ACSL1 (acyl-CoA synthetase long-chain family member 1)
Ortholog Status:The human GeneID 2180 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Acsl1
Fold Change:1.27
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012820.1NP_036952.1NC_005115.2 range: 49036891..49081415, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005792microsomeCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIDA (11319232)
GO:0005778peroxisomal membraneCellular ComponentIDA
GO:0005777peroxisomeCellular ComponentIEA
GO:0005741mitochondrial outer membraneCellular ComponentIEA
GO:0005741mitochondrial outer membraneCellular ComponentIDA (17478130)
GO:0005739mitochondrionCellular ComponentISS
GO:0005739mitochondrionCellular ComponentIEA
GO:0005625soluble fractionCellular ComponentIDA (11319232)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIDA (15601973)
GO:0016874ligase activityMolecular FunctionIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0003987acetate-CoA ligase activityMolecular FunctionTAS (2341402)
GO:0004467long-chain-fatty-acid-CoA ligase activityMolecular FunctionIDA (11319222)
GO:0004467long-chain-fatty-acid-CoA ligase activityMolecular FunctionIEA
GO:0014070response to organic cyclic substanceBiological ProcessIEP (10777552)
GO:0010033response to organic substanceBiological ProcessIDA (11319222)
GO:0008152metabolic processBiological ProcessIEA
GO:0007584response to nutrientBiological ProcessIEP (15811777)
GO:0006631fatty acid metabolic processBiological ProcessIMP (17028193)
GO:0006631fatty acid metabolic processBiological ProcessIEA
GO:0006629lipid metabolic processBiological ProcessTAS (2341402)
GO:0006629lipid metabolic processBiological ProcessIEA
GO:0042493response to drugBiological ProcessIEP (17284823)
Other Database Cross Links
NCBI Entrez Gene:25288