ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NEIL2

Full Name:

nei like 2 (E. coli)

Alias:

FLJ31644|MGC2832|MGC4505|NEH2|NEI2

Organism:

Homo sapiens (Human)

Chromosome:

8

Genetic Location:

8p23.1

Physical Location:

11664665-11682262 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D8S550

10918926

Region:		8918926-12918926
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_145043.1	NP_659480.1	NC_000008.9 range: 11664665..11682262

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003684	damaged DNA binding	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	Molecular Function	IEA
GO:0006289	nucleotide-excision repair	Biological Process	IEA
GO:0006284	base-excision repair	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000154328

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: