ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FYN

Full Name:

FYN oncogene related to SRC, FGR, YES

Alias:

MGC45350|SLK|SYN

Organism:

Homo sapiens (Human)

Chromosome:

6

Genetic Location:

6q21

Physical Location:

112089177-112301319 on NC_000006.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

FYN

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
FYN	2	Alcoholism
FYN	2	Alcohol-Related Disorders

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002037.3	NP_002028.1	NC_000006.10 range: 112089177..112301319, complement
NM_153047.1	NP_694592.1	NC_000006.10 range: 112089177..112301319, complement
NM_153048.1	NP_694593.1	NC_000006.10 range: 112089177..112301319, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (10858437)
GO:0005768	endosome	Cellular Component	IDA (15611048)
GO:0005886	plasma membrane	Cellular Component	IDA (15611048)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	IPI (14993658)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	NAS (7822789)
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0007631	feeding behavior	Biological Process	TAS (8264796)
GO:0007612	learning	Biological Process	TAS (1361685)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007243	protein kinase cascade	Biological Process	TAS (1361685)
GO:0006816	calcium ion transport	Biological Process	NAS (7822789)
GO:0006468	protein amino acid phosphorylation	Biological Process	NAS (7822789)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0050852	T cell receptor signaling pathway	Biological Process	IDA (7722293)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000010810

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: