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Gene Information
Gene ID:25383
Symbol:Apobec1
Full Name:apolipoprotein B editing complex 1
Alias:REPR
Organism:Rattus norvegicus (Rat)
Chromosome:4
Genetic Location:4q42
Physical Location:159033169-159048107 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 339    Symbol (Name): APOBEC1 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1)
Ortholog Status:The human GeneID 339 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Apobec1
Fold Change:-1.23
Tissue:Caudate-putamen
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012907.2NP_037039.1NC_005103.2 range: 159033169..159048107, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA
GO:0005634nucleusCellular ComponentNAS
GO:0005737cytoplasmCellular ComponentIDA
GO:0003723RNA bindingMolecular FunctionNAS
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0017091AU-rich element bindingMolecular FunctionISS
GO:0004126cytidine deaminase activityMolecular FunctionIDA (8511591)
GO:0005515protein bindingMolecular FunctionIPI
GO:0004126cytidine deaminase activityMolecular FunctionNAS
GO:0042157lipoprotein metabolic processBiological ProcessIEA
GO:0042157lipoprotein metabolic processBiological ProcessISS
GO:0042158lipoprotein biosynthetic processBiological ProcessISS
GO:0042493response to drugBiological ProcessIDA (11116209)
GO:0042953lipoprotein transportBiological ProcessISS
GO:0045471response to ethanolBiological ProcessIDA (9826530)
GO:0046087cytidine metabolic processBiological ProcessIC
GO:0048255mRNA stabilizationBiological ProcessISS
GO:0051592response to calcium ionBiological ProcessIDA (11027667)
GO:0032869cellular response to insulin stimulusBiological ProcessIEP (9667237)
GO:0016556mRNA modificationBiological ProcessISS
GO:0006397mRNA processingBiological ProcessIEA
GO:0006970response to osmotic stressBiological ProcessIDA (10939631)
GO:0010043response to zinc ionBiological ProcessIEP (10498758)
GO:0010332response to gamma radiationBiological ProcessISS
GO:0016554cytidine to uridine editingBiological ProcessIDA (12020819)
GO:0016554cytidine to uridine editingBiological ProcessIEA
GO:0016554cytidine to uridine editingBiological ProcessISS
GO:0016556mRNA modificationBiological ProcessIDA (8511591)
GO:0016556mRNA modificationBiological ProcessIEA
GO:0051607defense response to virusBiological ProcessIDA (15296758)
Other Database Cross Links
NCBI Entrez Gene:25383
RGD:2133
Ensembl:ENSRNOG00000015411
dbSNP:Apobec1